Background: Laparoscopic appendectomy is the most common emergent surgery, and various techniques were used for the closure of appendicular stump and appendiceal artery. Aim: This study aimed to compare the clinical impacts of absorbable polymeric clips and traditional metallic clips. Methods: We reviewed the laparoscopic appendectomies performed from June 2020 to May 2021 in a medical center. We analyzed the characteristics and intraoperative and postoperative data of patients receiving absorbable or metallic clips during laparoscopic appendectomy. Results: A total of 120 patients were enrolled in this study. Fifty‑nine patients received lapro‑clips for the ligation of appendicular stump and artery (Group A), whereas 61 patients received titanium clips (Group B). The operative time for both groups was 63.6 ± 18.9 min and 65.5 ± 19.2 min, respectively (P = 0.586). There was no significant difference in postoperative complications (P = 0.958). The length of hospital stay for each group was 3.07 ± 1.14 days and 2.90 ± 1.18 days, respectively (P = 0.435). Conclusion: The application of absorbable polymetric clips is feasible and safe with the additional benefit of leaving no foreign body for the closure of appendicular stump and ligation of appendiceal artery for laparoscopic appendectomy.