In this study, we present a case of Grade IV diabetic foot ulcer (DFU) and its management with Vrana ropana chikitsa along with Ayurvedic precision medicines. A 72‑year‑old male patient having grade IV DFU was given the Vrana ropana chikitsa with precision medicines. The bacterial profile and antibiotic resistance, and wound characteristics were monitored before and after the treatment. After the treatment, significant progressions were found in the patient. There was a decrease in the growth of Staphylococcus aureus in the wound after the treatment. Doxycycline and erythromycin‑resistant isolates were switched to antibiotic sensitive strains with Vrana ropana chikitsa. Progression of Grade IV ulcer to healing wound was found in the patient. A case of Grade IV DFU with drug‑resistant S. aureus was managed with the alternative treatment of Vrana ropana chikitsa and showed improved wound healing.