篇名 | Postpartum Fatal Fulminant Hepatic Failure Presenting with Persistent Hypoglycemia Due to Acute Fatty Liver of Pregnancy |
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卷期 | 41:2 |
作者 | Anant Parasher 、 Vandana Mohan |
頁次 | 099-104 |
關鍵字 | Acute fatty liver 、 encephalopathy 、 fatty infiltration 、 pregnancy 、 MEDLINE 、 Scopus |
出刊日期 | 202104 |
DOI | 10.4103/jmedsci.jmedsci_179_20 |
Acute fatty liver of pregnancy (AFLP) is a sudden and devastating illness which occurs mostly around the 36th week of gestation in pregnant females. It is characterized by microvesicular fatty infiltration of the liver which eventually results in encephalopathy and hepatic failure. It carries significant perinatal and maternal mortality and requires early diagnosis and intervention to prevent maternal and fetal death. The foremost cause of AFLP is thought to be due to a mitochondrial dysfunction in the oxidation of fatty acids leading to their continuous accumulation in the hepatocytes. Early diagnosis is extremely important and the only definitive therapy is delivery. Here, we present the case of a 28‑year‑old pregnant female presenting with abdominal pain, vomiting, and jaundice who was diagnosed with AFLP and gradually worsened postpartum. Due to persistent hypoglycemia and rapidly developing fulminant hepatic failure, the patient expired 5 days after admission.