Herein, we illustrated a rare patient with artery of Percheron (AOP) infarction who presented as reversible coma. Through the presentation of this case and literature review, we point out the diagnostic challenges in this entity. Second, we discuss the possible mechanisms of recovery of consciousness in this stroke subtype and remark the need for future reports using advanced functional neuroimaging techniques to clarify the unknown mechanisms underlying the evolution of the clinic in AOP infarction. We believe that the results of these studies may also give crucial insights regarding the processing of some critical functions such as sleep, arousal, and consciousness as well as our understanding of various consciousness disorders.