Background: Medical marijuana is a new concept in using legalized cannabis for the management of medical disorders. At present, this new concept is used in many countries. Medical marijuana might be useful for the management of many disorders including tuberculosis. Here, the authors study on immune response alteration resulted from marijuana use for tuberculosis management. Methods: The standard bioinformatics clinical pathway analysis is performed to access the interrelationship between pharmacotoxicological process of active ingredients of marijuana and pathophysiological process of tuberculosis with T‑helper (Th) 1/Th7 response as a linkage node. Results: From the interrelationship study, there is a coacting phenomenon that can promote infection. Conclusions: Marijuana can impair Th1/Th7 response. Marijuana is not benefit for tuberculosis management.