Acute renal infarction is an uncommon disease, which is frequently misdiagnosed or diagnosed late because of its nonspecific clinical presentation, and may result in irreversible damage to the renal parenchyma. Here, we present a case of acute renal infarction in a 51‑year‑old male, presenting with left flank pain and being diagnosed through computed tomography. We successfully performed catheter‑directed thrombolysis to rescue the ischemic renal tissue and preserve the renal function.