The aim of this study was to investigate the three heart chambers’ cardiac chloroma in a patient with non‑M3 acute myeloid leukemia. In this report, we presented a 38‑year‑old man in good health with no relevant history of any specific diseases before. There was swelling of the right lower extremity with the first impression of acute deep vein thrombosis. Anticoagulant treatment was initiated after duplex sonography of lower limbs confirmed this diagnosis. Our case had a complete response to chemotherapy regimen, and radiotherapy was not needed and then bone marrow transplant was performed successfully.