篇名 | Application of Stereotactic Ablative Radiotherapy in Hepatocellular Carcinoma Patients with Child–Turcotte–Pugh Class B Liver Function |
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卷期 | 38:5 |
作者 | Cheng‑Hsiang Lo 、 Wen‑Yen Huang 、 Wei‑Chou Chang 、 Hsing‑Lung Chao 、 Kuen‑Tze Lin 、 Jen‑Fu Yang 、 Yi‑Chiao Cheng 、 Chun‑Shu Lin |
頁次 | 204-210 |
關鍵字 | Hepatocellular carcinoma 、 stereotactic ablative radiotherapy 、 stereotactic body radiotherapy 、 Child–Turcotte–Pugh class B 、 MEDLINE 、 Scopus |
出刊日期 | 201810 |
DOI | 10.4103/jmedsci.jmedsci_156_17 |
Background: The aim of this study is to evaluate the outcomes and prognostic factors in patients with hepatocellular carcinoma (HCC) and Child–Turcotte–Pugh (CTP) class B liver function after stereotactic ablative radiotherapy (SABR). Materials and Methods: This retrospective study evaluated patients with HCC and impaired liver function who underwent SABR between December 2007 and August 2016. All patients had CTP class B liver function before treatment. Local control (LC) rate, overall survival (OS) rate, prognostic factors, and radiation‑related toxicity were evaluated. Results: This study included 34 patients. The majority had a CTP score of B7 (52.9%) and advanced HCC (91.2%). The median survival time was 4.8 months, and the 1‑year OS rate was 21.4%. Only the tumor number (multiple vs. single) was identified as an independent predictor of survival. The 1‑year LC rate was 95.8%. Eight patients (23.5%) developed the radiation‑induced liver disease, and 15 (44.1%) had a CTP score decline of ≥2 within 3 months. Other toxicities were generally tolerable. Conclusion: SABR may be considered as an alternative option for patients with HCC and CTP class B liver function, particularly for those with a single lesion.