Takotsubo cardiomyopathy (TCM), also known as stress cardiomyopathy, is a type of nonischemic cardiomyopathy, in which there is a sudden temporary weakening of the muscular portion of the heart. It is usually the result of severe emotional or physical stress, such as a sudden illness, the loss of a loved one, or a serious accident. The most commonly discussed possible mechanism is stress‑induced catecholamine release, with toxicity to and subsequent stunning of the myocardium. We describe a rare case of TCM in a young woman after receiving cosmetic facial mole removal under local laser therapy. She denied history of systemic disease. The patient had chest pain, shortness of breath, elevated cardiac enzymes, and ST‑segment elevations in V1–V4. There is absence of significant coronary artery disease in emergent cardiac catheterization. Left ventriculography revealed apical ballooning akinesis with basal hyperkinesis during systole. Takotsubo cardiomyopathy was impressed under above findings. The patient was successfully treated with medical conservative treatment without complication.