篇名 | Content of Markers of Respiratory Tract Remodeling in Exhaled Breath Condensate in Children Suffering from Bronchial Asthma |
---|---|
卷期 | 37:5 |
作者 | Olena Kostiuntynivna Koloskova 、 Tetiana Mykhailivna Bilous 、 Galyna Anatoliivna Bilyk 、 Tetiana Olexandrivna Lobanova 、 Mariana Viktorivna Dikal 、 Volodymyr Volodymyrovich Bilous |
頁次 | 190-194 |
關鍵字 | Bronchial asthma 、 children 、 exhaled breath condensate 、 bronchial remodeling 、 MEDLINE 、 Scopus |
出刊日期 | 201710 |
DOI | 10.4103/jmedsci.jmedsci_11_17 |
This study investigated to detect the content of remodeling markers of the respiratory tract in the exhaled breath condensate (EBC) of children with bronchial asthma (BA). Materials and Methods: The study was in clinical groups of children with BA were formed on the indices in sputum supernatant: the Group I ‑ “a high risk group” of bronchial remodeling (37 patients with vascular endothelial growth factor (VEGF) more than 80 ng/ml, and matrix metalloproteinase‑9 (MMP‑9) more than 5.2 ng/ml), the Group ІІ ‑ “a moderate risk” of bronchial remodeling (41 patients with VEGF more than 80 ng/ml, and MMP‑9 <5.2 ng/ml, or VEGF <80 ng/ml, and MMP‑9 more than 5.2 ng/ml), the Group ІІІ ‑ “a low risk” of bronchial remodeling (38 patients with VEGF did not achieve 80 ng/ml, and ММР‑9 <5.2 ng/ml). Results: The results obtained enable to believe that in EBC of children with a high risk of bronchial remodeling was higher azoalbumin olysis (1.8 ml/h comparison of Group II ‑ 1.5 ml/h, P = 0.038, and Group III ‑ 1.4 ml/h, P = 0.007), high catalase activity (81.26 comparison of other group ‑ 50.7, P = 0.06, and 47.07, P = 0.052 μmol/min/mg of protein). Furthermore, in the clinical Group I, the content of nitrogen monoxide metabolites (53.5 mcmol/L) comparison of Group II of children (48.7 mcmol/L, P = 0.28) and the Group III (41.7 mcmol/L, P = 0.085). Conclusions: In children with a “high risk” of respiratory tract remodeling more significant inflammatory process in the bronchi is found than in children with a “low risk.”