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Journal of Medical Sciences MEDLINEScopus

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篇名 Overview of Clinical Trials for Dry Age‑related Macular Degeneration
卷期 37:4
作者 Wen-Sheng ChengDa‑Wen LuChiao‑Hsi ChiangCharn‑Jung Chang
頁次 130-136
關鍵字 Age‑related macular degenerationretinal pigment epitheliumphotoreceptorsage‑related eye disease studychoroidal perfusion enhancersMEDLINEScopus
出刊日期 201708
DOI 10.4103/jmedsci.jmedsci_115_16

中文摘要

英文摘要

The overall goal of treating age‑related macular degeneration (AMD) is to target the underlying cause of the disease and prevent, or at least slow down, the loss of vision, which requires the preservation of the choroid, retinal pigment epithelium (RPE), and photoreceptors. At present, there is no proven drug treatment for dry AMD; however, the cessation of smoking and treatments based on the age‑related eye diseases study vitamin formula combined with a healthy diet are considered the only options for slowing disease progression. A number of pharmaceutical agents are currently under evaluation for the treatment of dry AMD using strategies such as reduction RPE and photoreceptor loss, neuroprotection, visual cycle modulators, suppression of inflammation, prevention of oxidative damage, and choroidal perfusion enhancers. The hope is that some of these therapies will achieve significant improvement to current management and prevent future loss of vision in this devastating eye condition.

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