Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous syndrome affecting multiple organ systems and featuring highly variable clinical manifestations. Epilepsy occurs in more than two-thirds of TSC victims, and up to one-third of TSC sufferers will develop infantile spasms (IS), a condition that is often medically intractable. Vigabatrin (VGB) has proved to be an effective antiepileptic drug for the treatment of IS resulting from TSC. A number of previous studies have indicated that earlier control of epilepsy contributes to a better prognosis for TSC-related mental retardation. To our knowledge, however, reports of treatment with VGB for IS for TSC victims are limited in Taiwan. Herein, we report on a case of IS associated with TSC that was effectively treated with VGB; successful treatment was defined as the patient achieving a complete recovery of electroencephalogram (EEG) recordings and being seizure free for at least six months. Moreover, we followed up this case for a period of more than one year from diagnosis, during which time the patient was seizure free and their psychomotor development remained within normal milestones.