Intussusception is less common in adults than in children. Intussusception in adults is associated with an identifiable etiology in 90% of cases. Lipoma is the second most common type of benign tumors of the colon, after adenomatous polyp. Small lipomas are usually asymptomatic, but giant lipomas are often presented as abdominal pain, vomiting, diarrhea, and bleeding. We reported a case presenting with ileocolic intussusception and found a giant colonic lipoma incidentally under colonoscopy. After surgical resection, the histopathologic examination of the specimen showed the configuration of submucosal lipoma, measuring 7.0×4.0×3.0 cm3 in diameter. Along with a review of the literature, the incidence, symptoms and treatment of colonic lipomas are discussed.