A 63-year-old woman who suffered from recurrent Vogt-Koyanagi-Harada disease with serous retinal detachments received a 5 mg intravitreal injection of triamcinolone acetonide in both eyes during the acute phase of the disease. The following variables were evaluated: visual acuity, intraocular pressure, and height of serous retinal detachment using optical coherence tomography. The optical coherence tomography images showed a marked decrease in the degree of retinal detachment in the first week after the injection, with subsequent return to normal retinal thickness in both eyes. Thus, intravitreal triamcinolone acetonide provides short-term improvement in visual acuity and the serous retinal detachments associated with Vogt- Koyanagi-Harada disease. These findings should be followed up with further studies to evaluate the long-term effects of treatment.