Renal cell carcinoma (RCC) is a common aggressive genitourinary tract tumor and in which distant metastases eventually develop. It is known to have potential to metastasize to almost any site, but metastatic RCC to the duodenum is extremely rare. We discuss a 57-year-old male patient who had undergone a right radical nephrectomy 12 years previously and free of disease for RCC presented with a 3-days history of shortness of breath, fatigue, dyspepsia, black tarry stools, and generalized weakness. The diagnosis made from the biopsy specimens on upper gastrointestinal panendoscopy study was metastatic RCC in the duodenum. He underwent the surgical exploration for pancreaticoduodenectomy subsequently. He had an uneventful recovery with Sutent (Sunitinib malate) was used after surgery for adjuvant target therapy and there was no evidence of recurrence 6 months after the procedure.