Angiosarcoma of the head and neck is a rare tumor of vascular origin that occurs almost exclusively in the scalp andforehead region. Primary angiosarcomas of the submandibular gland are extremely rare. Here we report one such case.The patient was referred for evaluation of a neck mass in the right submandibular region that had rapidly enlarged withinthe previous half year. Computed tomography scanning showed a hypervascular tumor within the submandibular gland.Excision of the submandibular gland was attempted. The histopathology revealed characteristic features of high grade angiosarcoma,which revealed a predominant solid tumor mass with few vascular channels which composed with irregularand freely anastomosing channels lined by marked pleomorphic spindle endothelial cells. Positive CD34 and P53 expressionsindicated malignant vascular origin tumor. Such a rare case of angiosarcoma occurs in the salivary gland presentingas a neck mass with variable imaging and cytological features make pre-operative diagnosis diffi cult. Spectrum of vasculartumors are variable, and excision biopsy should be performed to establish the diagnosis. The fi nal diagnosis must bemade according to histological examination, immunocytochemical studies and clinical behaviors.