The pedicled anterolateral thigh (ALT) fl ap is safe and reliable for repairing abdominal wall defects. This fl ap has a longpedicle and a wide arc of rotation, and it can extend from above the umbilicus and the lower back to the upper thigh, includingthe groin and perineum. The ALT fl ap is a technically simple muscle fl ap that permits primary closure and minimalmorbidity of the donor site. We report a case of successful reconstruction of a large abdominal defect after tumorresection by using a pedicled vastus lateralis muscle fl ap. Literature review on the clinical applications of the ALT andpedicled vastus lateralis muscle fl ap for reconstruction of soft tissue defects were performed.