Acute bacterial parotitis (ABP) is an uncommon infection of the parotid gland that tends to occur in immunocompromised patients. The most predominant pathogen causing ABP is Staphylococcus aureus. We report a case of a patient with valvular heart disease and dilated cardiomyopathy accompanied by congestive heart failure (NYHA, Fc IV). During hospitalization, the cardiac preload of patients is reduced by restricting their fluid intake and administering appropriate diuretic therapy. Unfortunately, our patient developed nosocomial pneumonia and ABP with methicillin-resistant Staphylococcus aureus (MRSA) infection and subsequent bacteremia with sepsis. Herein, we emphasize that the maintenance of good oral hygiene, adequate dehydration, and proper antimicrobial therapy in the event of concurrent infection may reduce the occurrence of ABP in patients with excessive dehydration due to severe heart failure.