Lipomas, which are benign tumors composed of mature lipocytes, are the most common mesenchymal soft tissue tumors. They rarely grow beyond 10 cm in their cutaneous localization, which is most often on the trunk and extremities. It is unusual for lipomas to grow larger than a few grams or to present on the axillary region. In such cases, mammography and ultrasonography are typically considered for complete assessment of giant axillary masses. Herein, we report on a 60-year-old woman who presented with an asymptomatic, huge soft tissue mass on the right axillary region. She underwent wide-excision surgery, and the mass was confirmed to be benign lipoma on pathological analysis. In this report, we present our case and review the literature concerning rare giant axillary lipomas.